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. 2021 Jun 15;22(12):6380. doi: 10.3390/ijms22126380

Figure 2.

Figure 2

Englerin-A reverses carrageenan-induced paw oedema and thermal hyperalgesia when given 2 h after carrageenan. (A) Time-course of paw oedema measured by callipers and (B) ipsilateral/ contralateral paw mass ratio, 4 h following induction of paw oedema by 2% Carrageenan. Data are mean ± S.E.M, n = 6–8. *** p < 0.001 versus baseline, # p < 0.05, versus vehicle, Two-way RM ANOVA, post-hoc Tukey test. (C) Thermal paw withdrawal thresholds measured at 1 and 3 h, respectively, after intra-plantar injections of carrageenan. Arrow indicates time of EA treatment (2 mg/kg i.p.). * p < 0.05, *** p < 0.001 versus baseline, ### p < 0.001 versus vehicle, Two-way ANOVA, post-hoc Tukey test. Data are mean ± S.E.M, n = 6–8.