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. 2021 Jun 15;22(12):6380. doi: 10.3390/ijms22126380

Figure 3.

Figure 3

Englerin-A reduces carrageenan-induced paw oedema and mechanical and thermal hyperalgesia, in both WT and TRPC5 KO mice. (A) Time-course of paw oedema measured by callipers and (B) ipsilateral/contralateral paw mass ratio 4 h following induction of paw oedema by 2% Carrageenan. Data are mean ± S.E.M, n = 8. * p < 0.05, *** p < 0.001 versus baseline, # p < 0.05, versus vehicle, Two-way ANOVA, post hoc Tukey test. (C) Myeloperoxidase (MPO) levels in paw exudates, 4 h after the induction of paw inflammation. Data are mean ± S.E.M, n = 8. * p < 0.05 versus vehicle, unpaired t-test. (D) Thermal and (E) mechanical paw withdrawal thresholds measured at baseline and at 1 and 3 or 2 and 4 h, respectively, after intra-plantar injections of carrageenan. * p < 0.05, ** p < 0.01, *** p < 0.001 versus baseline, # p < 0.05, ### p < 0.001 versus vehicle, Two-way RM ANOVA, post hoc Tukey test. Data are mean ± S.E.M, n = 8.