Table 1.
Location and function of GTPases in the islet β-cell.
| GTPases in β-Cells | Location | Function | References |
|---|---|---|---|
| Rac1 | Cytosol (GDP-loaded), PM (GTP-loaded) |
Cytoskeletal rearrangement | [63,64] |
| Cdc42 | Cytosol/Insulin-containing secretory granules (GDP-loaded), PM (GTP-loaded) | Cytoskeletal rearrangement/ Vesicle fusion |
[47,48,49,65,66] |
| Arf6 | Cytosol (GDP loaded), PM (GTP loaded) | Vesicle fusion | [50] |
| Rab27a | Insulin-containing secretory granules (GDP and GTP loaded) | Docking/priming | [67] |
| Rab37 | Cytosol (GDP loaded) Insulin-containing secretory granules (GTP loaded) | Docking/priming | [68] |
| Rab2a | Cytosol (GDP loaded) Perinuclear immature granules (GTP loaded) | Docking/priming | [69] |
| Rab3a | Cytosol (GDP loaded) Insulin-containing secretory granules (GTP loaded) | Docking/priming | [70] |
| Rap1 | Colocalized with insulin granules (GDP loaded), PM (GTP loaded) | Docking/priming | [71] |
PM, plasma membrane.