Table 5.

Inflammasomopathies versus IFNopathies.

INFLAMMASOMOPATHIES	IFNopathies
CLINICAL SIGNS Recurrent fever Serositis Arthritis Rash (e.g., urticarial rash) GI symptoms Neurological involvement	CLINICAL SIGNS Flu-like fever episodes TORCH-like syndrome without congenital infection Chilblains Raynaud’s phenomenon Panniculitis/lipodystrophy RF positive-JIA resistant to conventional DMARDs Autoimmune SLE—like phenotype Interstitial non-infectious lung disease
LABORATORY FINDINGS Elevated inflammatory markers (RCP, ESR, SAA)	LABORATORY FINDINGS Normal or slightly increased ESR and CRP with or without leucopeniaFluctuating low-titer ANA and other autoantibodies Leukocytes and IFN increased in cerebrospinal fluid IFN signature