. Author manuscript; available in PMC: 2021 Jun 25.

Published in final edited form as: Lancet Healthy Longev. 2020 Nov 12;1(3):e96–e105. doi: 10.1016/s2666-7568(20)30015-5

Table 2:

Association of circadian regulation and incident Alzheimer’s dementia after adjustment for demographics

	Amplitude		Acrophase		Interdaily stability		Intradaily variability
	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Age, 1-unit increase	1·11 (1·09–1·14)	<0·0001	1·12 (1·10–1·14)	<0·0001	1·12 (1·10–1·14)	<0·0001	1·11 (1·09–1·14)	<0·0001
Female sex	1·12 (0·81–1·56)	0·51	0·92 (0·70–1·24)	0·58	0·97 (0·72–1·31)	0·82	1·06 (0·78–1·47)	0·72
Education, 1-unit decrease	1·05 (1·00–1·09)	0·030	1·04 (1·00–1·09)	0·048	1·05 (1·00–1·09)	0·039	1·04 (1·00–1·09)	0·053
Amplitude, 1 SD decrease	1·39 (1·19–1·62)	<0·0001	..	..	..	..	..	..
Acrophase, 1-unit increase	..	..	1·02 (0·94–1·11)	0·61	..	..	..	..
Interdaily stability, 1 SD decrease	..	..	..	..	1·10 (0·94–1·27)	0·24	..	..
Intradaily variability, 1 SD increase	..	..	..	..	..	..	1·22 (1·04–1·42)	0·017