Table 3:
Secondary analyses of associations of circadian regulation with MCI and Alzheimer’s dementia within participants with MCI, and risk of conversion from MCI to Alzheimer’s dementia within 3 years
| Amplitude |
Acrophase |
Interdaily stability |
Intradaily variability |
|||||
|---|---|---|---|---|---|---|---|---|
| Risk ratio (95% CI) | p value | Risk ratio (95% CI) | p value | Risk ratio (95% CI) | p value | Risk ratio (95% CI) | p value | |
| Circadian regulation and incident MCI within participants who were cognitively intact at baseline (n=935)* | ||||||||
| Age, 1-unit increase | 1·08 (1·06–1·10) | <0·0001 | 1·08 (1·07–1·10) | <0·0001 | 1·08 (1·07–1·10) | <0·0001 | 1·08 (1·06–1·10) | <0·0001 |
| Female sex | 1·24 (0·75–1·99) | 0·39 | 1·34 (0·84–2·14) | 0·21 | 1·25 (0·76–2·01) | 0·37 | 1·23 (0·75–2·03) | 0·41 |
| Education, 1-unit decrease | 1·00 (0·97–1·04) | 0·89 | 1·00 (0·97–1·04) | 0·95 | 1·00 (0·96–1·03) | 0·94 | 1·00 (0·96–1·03) | 0·78 |
| Amplitude, 1 SD decrease | 1·07 (0·96–1·19) | 0·21 | .. | .. | .. | .. | .. | .. |
| Acrophase, 1-unit increase | .. | .. | 1·01 (0·94–1·07) | 0·87 | .. | .. | .. | .. |
| Interdaily stability, 1 SD decrease | .. | .. | .. | .. | 1·01 (0·91–1·12) | 0·83 | .. | .. |
| Intradaily variability, 1 SD increase | .. | .. | .. | .. | .. | .. | 1·02 (0·91–1·14) | 0·70 |
| Circadian regulation and incident Alzheimer’s dementia within participants with MCI (who had MCI at baseline or developed MCI during follow-up; n=586)* | ||||||||
| Age, 1-unit increase | 1·07 (1·07–1·09) | <0·0001 | 1·08 (1·06–1·11) | <0·0001 | 1·08 (1·06–1·11) | <0·0001 | 1·07 (1·05–1·10) | <0·0001 |
| Female sex | 1·27 (0·90–1·80) | 0·17 | 1·05 (0·78–1·44) | 0·76 | 1·19 (0·86–1·69) | 0·30 | 1·28 (0·90–1·82) | 0·15 |
| Education, 1-unit decrease | 1·06 (1·01–1·11) | 0·019 | 1·05 (1·00–1·09) | 0·050 | 1·05 (1·01–1·10) | 0·022 | 1·05 (1·01–1·15) | 0·025 |
| Amplitude, 1 SD decrease | 1·45 (1·24–1·72) | <0·0001 | .. | .. | .. | .. | .. | .. |
| Acrophase, 1-unit increase | .. | .. | 0·99 (0·91–1·09) | 0·89 | .. | .. | .. | .. |
| Interdaily stability, 1 SD decrease | .. | .. | .. | .. | 1·21 (1·02–1·44) | 0·028 | .. | .. |
| Intradaily variability, 1 SD increase | .. | .. | .. | .. | .. | .. | 1·36 (1·15–1·60) | 0·0003 |
| Circadian regulation and odds of conversion from MCI to Alzheimer’s dementia within 3 years (n=470)† | ||||||||
| Age, 1-unit increase | 1·05 (1·01–1·10) | 0·0089 | 1·09 (1·06–1·14) | <0·0001 | 1·10 (1·06–1·14) | <0·0001 | 1·06 (1·02–1·10) | 0·0069 |
| Female sex | 1·40 (0·73–2·97) | 0·34 | 0·94 (0·55–1·63) | 0·82 | 1·07 (0·60–1·99) | 0·82 | 1·40 (0·73–2·89) | 0·34 |
| Education, 1-unit decrease | 1·10 (1·01–1·20) | 0·039 | 1·08 (0·99–1·17) | 0·071 | 1·11 (1·02–1·21) | 0·012 | 1·13 (1·04–1·24) | 0·0070 |
| Amplitude, 1 SD decrease | 2·08 (1·53–2·93) | <0·0001 | .. | .. | .. | .. | .. | .. |
| Acrophase, 1-unit increase | .. | .. | 1·01 (0·87–1·17) | 0·89 | .. | .. | .. | .. |
| Interdaily stability, 1 SD decrease | .. | .. | .. | .. | 1·35 (1·01–1·84) | 0·046 | .. | .. |
| Intradaily variability, 1 SD increase | .. | .. | .. | .. | .. | .. | 1·97 (1·43–2·79) | <0·0001 |
MCI=mild cognitive impairment.
*
Data are hazard ratio (95% CI).
†
Data are odds ratio (95% CI).