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Genome Organization of HCV and HGV/GBV-C. (A) Organization of the HCV genome, showing the 5′ and 3′ untranslated regions, the single open reading frame and its cleavage sites. (B) The relative sizes of the resulting HCV proteins and what is currently understood of their functions. (C) Genome organization of HGV/GBV-C, with genes homologous to those of HCV indicated; note the lack of a protein corresponding to the capsid protein of HCV.
