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. 2021 Jun 25;16(6):e0253537. doi: 10.1371/journal.pone.0253537

Table 2. Factors associated with pre-diabetes and type 2 diabetes according to diagnosis by HbA1c or FPG.

Variable Odds ratio (95% CI)
Pre-diabetes compared to normoglycaemia Type 2 diabetes compared to normoglycaemia
HbA1c ADA P HbA1c WHO-IEC P FPG ADA P HbA1c ADA P HbA1c WHO-IEC P FPG ADA P
Male 0.80 (0.64–0.99) .045 1.03 (0.76─1.40) .861 1.98 (1.46─2.69) < .001 1.96 (1.25–3.07) .003 2.20 (1.42─3.41) < .001 2.45 (1.55─3.87) < .001
Age ≥65 years 1.38 (1.10–1.74) .006 1.62 (1.17─2.23) .004 1.52 (1.12─2.07) .008 2.60 (1.60–4.23) < .001 2.41 (1.50─3.87) < .001 2.63 (1.59─4.37) < .001
Married or cohabiting 0.81 (0.62–1.07) .138 0.63 (0.45─0.89) .009 0.65 (0.47─0.91) .013 0.93 (0.56–1.57) .796 0.95 (0.58─1.58) .853 0.84 (0.50–1.40) .496
Health rating, very good or good 0.60 (0.43–0.84) .003 0.75 (0.49─1.15) .188 0.54 (0.37─0.79) .001 0.27 (0.16–0.44) < .001 0.33 (0.21─0.52) < .001 0.32 (0.20─0.52) < .001
Primary education only 1.26 (0.96–1.65) .1 1.24 (0.87─1.79) .239 1.61 (1.15–2.26) .005 2.04 (1.27–3.28) .003 1.89 (1.20─2.99) .006 2.29 (1.42–3.68) .001
Current smoker 1.67 (1.11─2.50) .014 0.96 (0.55─1.67) .887 1.05 (0.63–1.77) .849 1.58 (0.77–3.26) .215 1.20 (0.60─2.39) .6 1.18 (0.57–2.43) .652
High alcohol intake 0.86 (0.56–1.33) .5 1.35 (0.75─2.43) .324 1.73 (1.04–2.88) .034 0.27 (0.07–1.15) .076 0.30 (0.07─1.27) .1 0.77 (0.27–2.21) .632
Low-level physical activity 1.21 (0.95–1.55) .132 0.85 (0.61─1.18) .325 0.97 (0.70–1.34) .841 1.08 (0.68–1.71) .752 0.96 (0.61─1.51) .861 0.99 (0.62–1.59) .969
Poor diet qualitya 1.24 (0.99–1.56) .061 1.34 (0.98─1.82) .063 1.64 (1.22–2.21) .001 1.66 (1.08–2.57) .022 1.57 (1.03─2.40) .037 1.80 (1.15–2.82) .01
Overweight or obeseb 1.45 (1.11–1.89) .007 1.71 (1.14─2.58) .01 3.15 (1.97–5.05) < .001 2.86 (1.49–5.47) .002 2.61 (1.37─4.95) .003 4.13 (1.89–9.05) < .001
Hypertensionc 1.40 (1.12–1.75) .003 1.55 (1.14─2.11) .005 2.28 (1.68–3.09) < .001 3.53 (2.21–5.65) < .001 3.23 (2.04─5.10) < .001 3.52 (2.17–5.71) < .001
High triglyceridesd 0.99 (0.73–1.33) .93 1.35 (0.92─1.98) .13 2.10 (1.48–2.99) < .001 4.04 (2.57–6.34) < .001 4.28 (2.77─6.60) < .001 5.43 (3.45–8.55) < .001
Low HDL-Ce 1.35 (0.99–1.84) .059 1.24 (0.83─1.85) .3 2.17 (1.52–3.09) < .001 6.40 (4.04–10.12) < .001 5.71 (3.70─8.82) < .001 5.23 (3.31–8.24) < .001

Univariate multinomial logistic regression.

aBottom 40% DASH score.

bBMI ≥25.

cSystolic BP ≥140 or diastolic BP ≥90 or on anti-hypertensive medications.

dTriglycerides ≥1.7.

eHDL-C <1.03 males or <1.29 females.