Table 3.
Laboratory findings of individual patients with CASPR2 antibody-associated disease in the present study
| Parameter | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 |
|---|---|---|---|---|---|---|---|---|
| Abnormal neuroimaging | N | N | N | N | N | Y (PRES) | N | Y (thalamus, internal capsule, brainstem, cerebellar) |
| Abnormal EEG | N | N | ND | N | ND | N | ND | N |
| Abnormal ENMG | Y (NMT) | Y (NMT) | N | Y (NMT) | Y (NMT) | Y (sensorimotor axonal neuropathy) | ND | N |
| Abnormal ECG | Y (tachycardia) | Y (tachycardia) | Y (tachycardia, U waves) | N | Y (tachycardia) | Y (tachycardia) | Y (tachycardia, ventricular ectopics) | Y (tachycardia) |
| Cardiac autonomic dysfunction (AFT) | Y | Y | Y | Y | Y | ND | ND | ND |
| Abnormal PSG | Y (absent sleep stages) | ND | ND | ND | ND | ND | ND | ND |
| CSF pleocytosis | N | N | N | N | N | Y | ND | Y |
| Hyponatremia | N | Y | N | N | Y | Y | N | N |
| Other autoantibodies | N | N | N | N | N | N | Y (AchR antibody) | N |
| Abnormal CT chest and abdomen | N | N | N | N | ND | N | Y (thymoma) | N |
| Abnormal PET CT/MRI | ND | N | ND | ND | N | ND | ND | N |
AchR: Acetylcholine receptor; AFT: autonomic function test; CSF: cerebrospinal fluid; CT: computed tomogram; ECG: electrocardiogram; EEG: electroencephalogram; ENMG: electroneuromyogram; MRI: magnetic resonance imaging; N: no; ND: not done; NMT: neuromyotonia; PET: positron emission tomography; PRES: posterior reversible encephalopathy syndrome; PSG: polysomnogram; Y: yes