TABLE 2.
Potential targets of GQD on UC.
| Gene name | Target | Uniprot ID | Degree | ||
|---|---|---|---|---|---|
| ESR1 | Estrogen receptor alpha | P03372 | 47 | ||
| EGFR | Epidermal growth factor receptor erbB1 | P00533 | 38 | ||
| LCK | Tyrosine-protein kinase LCK | P06239 | 29 | ||
| SRC | Tyrosine-protein kinase SRC | P12931 | 27 | ||
| KDR | Vascular endothelial growth factor receptor 2 | P35968 | 27 | ||
| MMP2 | Matrix metalloproteinase 2 | P08253 | 26 | ||
| GSK3β | Glycogen synthase kinase-3 beta | P49841 | 26 | ||
| PTGS2 | Cyclooxygenase-2 | P35354 | 25 | ||
| MMP9 | Matrix metalloproteinase 9 | P14780 | 24 | ||
| HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | 23 | ||
| AR | Androgen receptor | P10275 | 23 | ||
| ABL1 | Tyrosine-protein kinase ABL | P00519 | 23 | ||
| PARP1 | Poly [ADP-ribose] polymerase-1 | P09874 | 22 | ||
| MTOR | Serine/threonine-protein kinase mTOR | P42345 | 17 | ||
| MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | 17 | ||
| RPSKB1 | Ribosomal protein S6 kinase 1 | P23443 | 17 | ||
| PIK3CA | PI-kinase p110-alpha subunit | P42336 | 16 | ||
| CDK4 | Cyclin-dependent kinase 4 | P11802 | 16 | ||
| PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | 15 | ||
| IL2 | Interleukin-2 | P60568 | 14 | ||
| MAPK14 | MAP kinase p38 alpha | Q16539 | 13 | ||
| MAPK8 | c-Jun N-terminal kinase 1 | P45983 | 12 | ||
| PIK3R1 | PI3-kinase p85-alpha subunit | P27986 | 12 | ||
| JAK2 | Tyrosine-protein kinase IAK2 | O60674 | 12 | ||
| MAPK2K1 | Dual specificity mitogen-activated protein kinase 1 | Q02750 | 11 | ||
| IGF1R | Insulin-like growth factor 1 receptor | P08069 | 11 | ||
| MPO | Myeloperoxidase | P05164 | 10 | ||
| RAC1 | Ras-related C3 botulinum toxin substrate 1 | P63000 | 9 | ||
| MAPK1 | MAP kinase ERK2 | P28482 | 8 | ||
| EP300 | Histone acetyltransferase p300 | Q09472 | 8 | ||
| CDC42 | Cell division control protein 42 homolog | P60953 | 8 | ||
| F2 | Thrombin | P00734 | 8 | ||
| SIRT1 | NAD-dependent control protein 42 homolog | Q96EB6 | 6 | ||
| RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | 6 | ||
| AKT1 | Serine/threonine-protein kinase AKT | P31749 | 5 | ||
| TNF | Tumor necrosis factor | P01375 | 5 | ||
| CASP3 | Caspase-3 | P42574 | 5 | ||
| MDM2 | P53-binding protein Mdm-2 | Q00987 | 5 | ||
| FYN | Tyrosine-protein kinase fyn | P06241 | 5 | ||
| NR3C1 | Glucocorticoid receptor | P04150 | 5 | ||
| PTK2 | Focal adhesion kinase 1 | Q05397 | 5 | ||
| ERBB2 | Receptor protein-tyrosine kinase erbB-2 | P04626 | 4 | ||
| BCL2L1 | Apoptosis regulator Bcl-X | Q07817 | 4 | ||
| STAT3 | Signal transducer and activator pf transcription 3 | P40763 | 3 | ||
| ICAM1 | Intercellular adhesion molecule-1 | P05362 | 3 | ||
| NFκB | Nuclear factor NF-kappa-B p105 subunit | P19838 | 3 | ||
| PTPN11 | Protein-tyrosine phosphatase 2C | Q06124 | 3 | ||
| SERPPINE1 | Plasminogen activator inhibitor-1 | P05121 | 3 | ||
| STAT6 | Signal transducer and activator of transcription 6 | P42226 | 3 | ||
| VEGFA | Vascular endothelial growth factor A | P15692 | 2 | ||
| MAPK3 | MAP kinase ERK1 | P27361 | 2 | ||
| CXCR4 | C-X-C chemokine receptor type 4 | P61073 | 2 | ||
| STAT1 | Signal transducer and activator of transcription 1 alpha/beta | P42224 | 2 | ||
| HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | 2 | ||
| XIAP | Inhibitor of apoptosis protein 3 | P98170 | 2 | ||
| FGF2 | Basic fibroblast growth factor | P09038 | 1 | ||
| ATM | Serine-protein kinase ATM | Q13315 | 1 | ||
| TGFB1 | Transforming growth factor | P01137 | 1 | ||
| PRKCD | Protein kinase C delta | Q05655 | 1 | ||