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Association between TIL and TMB (A) for the whole study sample and (B) for the MSS, MSI, and POLE/D1 phenotypes (logarithmic scale). The outlier in the MSS TIL-high group (TMB, 151.8 mt/Mb) had a non-hotspot POLE mutation (p.M444K). MSI, microsatellite instability; MSS, microsatellite stable; TIL, tumor-infiltrating lymphocytes; TMB, tumor mutational burden.
