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Frequencies and interactions of somatic genetic mutations in 10 selected signaling pathways (n = 499). Genetic alterations identified by the MSK-IMPACT assay were filtered by OncoKB to exclude mutations and copy number alterations of unknown significance as well as germline mutations. (A) Notch pathway. (B) WNT pathway. (C) TGF-β pathway. (D) TP53 pathway. (E) Hippo pathway. (F) MYC pathway. (G) PI3K pathway. (H) RAS pathway. (I) NRF2 pathway. (J) Cell cycle pathway.
