Table 1.

Adherence and efficacy in TM clinical trial for neuromuscular care

Authors	Disease	Design	Tool	Adherence	Outcome and efficacy	Strength	Limits
Portaro et al., 2018 [9]	FSHD	Open label, only treated group	Video-conferencing, telemonitoring of cardiorespiratory variables and telerehabilitation	All patients completed the study	Dropping of hospital admission for check-up; mild improvement in mood and emotional status of all the patients	Increased autonomy and self-monitoring preventing unnecessary hospital admission	Short duration (only 6 mo)
Zamarron et al., 2013 [10]	FSHD, ALS, DMD	Open label, only treated group	Remote monitoring of biological signals, video-conference	All patients completed the study	Acceptable level of satisfaction, dropping of hospital admission (18 to 3 in a previous period of same duration)	Long-term monitoring (5 yr); high level of feasibility	No existing standard of care in telemedicine; lag in video connections,
Martinez et al., 2021 [11]	Rare neuromuscular disease	Open, treated vs control	Tele-assistance via skype video-conferencing in 7 wk	All patients completed the study	Improving of quality of life in patients with moderate (both physical and psychosocial field) to severe (only psychosocial) disability degree	Design of the study, sample size, multidomain evaluation	technical problems; outcome measures not specific for diseases
Rockette-Wagner et al., 2021 [28]	Inflammatory myopathy	Open label, observational	Remote monitoring with wearable devices, FDA approved	29/44 (66%) provided valid data at baseline and follow up	Portable devices output variables had good reliability and validity for changes in the physical activity of IIM patients	Large patients cohort and longitudinal data	Output variables of portable devices not yet validated; cohort heterogeneity,
Sobieranska et al., 2020 [29]	DMD	Open label, observational	Tele rehabilitation with online workshop	45 respondent out of 69 enrolled (69%), 16 (23%) participated in live workshop; 132 total visualization of online videos	Online videos are more acceptable than live sessions; motor assessment results will be presented	Limited data available	Limited data available