Table 2.

STx2 LD₅₀ values with 95% confidence interval (CI) from Figure 2. Y or N indicates “yes” or “no” to the question whether LD₅₀ values are statistically different from DMSO or tamoxifen (TAM) (p < 0.05) using non-linear regression.

Compound	LD50 (95% CI) (pM)	Fold of DMSO (Different?)	Fold of TAM (Different?)
Figure 2A
DMSO	1.1 (0.7–1.7)	-	0.005 (Y)
TAM	234.3 (136.0–454.4)	213 (Y)	-
211	394.3 (120.0–3407.0)	358 (Y)	1.68 (N)
212	7.3 (4.0–13.4)	6.64 (Y)	0.031 (Y)
213	0.8 (0.5–1.5)	0.73 (N)	0.003 (Y)
214	1.2 (0.8–1.9)	1.09 (N)	0.005 (Y)
215	0.7 (0.4–1.0)	0.64 (N)	0.003 (Y)
216	5.8 (4.0–8.5)	5.27 (Y)	0.025 (Y)
217	56.9 (10.4–723.0)	51.7 (Y)	0.243 (N)
218	1.2 (0.8–1.9)	1.09 (N)	0.005 (Y)
219	0.8 (0.5–1.2)	0.73 (N)	0.003 (Y)
220	4.8 (3.3–6.8)	4.36 (Y)	0.020 (Y)
221	2.1 (1.4–3.4)	1.91 (Y)	0.009 (Y)
222	1.8 (1.3–2.5)	1.64 (N)	0.008 (Y)
223	23.1 (14.2–37.8)	21.0 (Y)	0.099 (Y)
224	79.8 (29.4–272.7)	72.5 (Y)	0.341 (N)
225	1.3 (0.6–2.9)	1.18 (N)	0.006 (Y)
226	41.5 (29.3–59.2)	37.7 (Y)	0.177 (Y)
Figure 2B
DMSO	2.0 (1.7–2.3)	-	0.010 (Y)
TAM	206.7 (165.3–259.4)	103 (Y)	-
263	5.2 (4.4–6.1)	2.60 (Y)	0.025 (Y)
264	8.9 (5.9–13.6)	4.45 (Y)	0.043 (Y)
265	12.6 (9.8–16.2)	6.30 (Y)	0.061 (Y)
266	3.6 (3.2–4.1)	1.80 (Y)	0.017 (Y)
267	3.9 (3.2–4.6)	1.95 (Y)	0.019 (Y)
268	4.5 (3.5–5.8)	2.25 (Y)	0.022 (Y)
269	toxic	-	-
270	36.6 (29.0–46.2)	18.3 (Y)	0.177 (Y)
271	43.2 (28.4–66.0)	21.6 (Y)	0.209 (Y)
Figure 2C
DMSO	1.2 (1.0–1.5)	-	0.002 (Y)
TAM	582.5 (440.7–791.5)	485 (Y)	-
336	42.4 (31.6–57.0)	35.3 (Y)	0.073 (Y)
337	10.2 (7.1–14.5)	8.50 (Y)	0.018 (Y)
338	1.8 (1.6–2.0)	1.50 (Y)	0.003 (Y)
339	1.0 (0.8–1.3)	0.83 (N)	0.002 (Y)
340	8.4 (6.3–11.4)	7.00 (Y)	0.014 (Y)
341	toxic	-	-
342	toxic	-	-
343	82.8 (48.7–141.2)	69.0 (Y)	0.142 (Y)