Table 1.

Effect of different treatments on the levels of diagnostic markers of rheumatoid arthritis (RF and anti-CCP).

Group	RF, Percent *	Anti-CCP, Percent *
Normal control	21.6 ± 0.67 a	7.74 ± 0.36 a
Negative control	78.4 ± 2.27 e, 263.45% (↑)	43.1 ± 1.45 f, 456.54% (↑)
MTX treated group	46.8 ± 2.31 c, 40.3% (↓)	22.6 ± 0.75 c, 47.6% (↓)
Ethanolic extract (100 mg/kg b.wt)	84.4 ± 2.22 e, 7.7% (↓)	36.4 ± 2.91 e, 15.6% (↓)
Ethanolic extract (200 mg/kg b.wt)	67.1 ± 3.11 d, 14.4% (↓)	29.6 ± 3.05 d, 31.4% (↓)
MTX + ethanolic extract (100 mg/kg b.wt)	41.5 ± 2.40 b, 47% (↓)	20.4 ± 0.95 c, 52.6% (↓)
MTX + ethanolic extract (200 mg/kg b.wt)	37.6 ± 2.15 bc, 52% (↓)	15.3 ± 0.52 b, 64.6% (↓)

RF, rheumatoid factor (mIU/mL); anti-CCP, anticyclic citrullinated peptide (IU/mL). * percentage increase or inhibition. Values are expressed as mean ± SE (n = 6 rats). In the same column, the presence of different letters (a–f) indicating a significant difference between groups using ANOVA in SPSS software (at p < 0.05), the letter “a” is the nearest result to the control while letter ”f” is the furthest from the control group.