Table 2.
Effect of different treatments on the levels of markers of inflammation (NF-ĸB, TNF-α and IL-10).
| Group | Proinflammatory Markers | Inflammatory Mediator | |
|---|---|---|---|
| NF-ĸB, Percent * | TNF-α, Percent * | IL10, Percent * | |
| Normal control | 4.56 ± 0.18 a | 36.9 ± 1.33 a | 98.6 ± 2.31 e |
| Negative control | 21.2 ± 0.65 e, (364.38% ↑) | 173.2 ± 3.23 e, (370% ↑) | 54.6 ± 1.85 a, (44.69% ↓) |
| MTX treated group | 8.65 ± 0.50 b, (59.2% ↓) | 93.4 ± 3.86 c, (46.1%↑) | 89.6 ± 2.09 d, (64.2% ↑) |
| Ethanolic extract (100 mg/kg b.wt) | 19.2 ± 1.09 d, (9.2% ↓) | 135.7 ± 3.81 d, (21.6% ↓) | 63.4 ± 2.46 b, (16.3% ↑) |
| Ethanolic extract (200 mg/kg b.wt) | 13.8 ± 0.59 c, (35% ↓) | 91.6 ± 3.83 c, (47.1% ↓) | 75.1 ± 3.31 c, (37.7% ↑) |
| MTX + ethanolic extract (100 mg/kg b.wt) | 8.29 ± 0.38 b, (60.9% ↓) | 83.5 ± 4.54 c, (51.8% ↓) | 95.8 ± 3.42 d,e, (75.7%↑) |
| MTX + ethanolic extract (200 mg/kg b.wt) | 7.66 ± 0.45 b, (63.69% ↓) | 69.4 ± 4.56 b, (59.9% ↓) | 99.3 ± 3.99 e, (82% ↑) |
NF-ĸB, nuclear factor kappa b (pg/mL); TNF-α, tumor necrosis factor (pg/mL); and IL-10, interleukin-10 (pg/mL). * Percentage increase or inhibition. Values are expressed as mean ± SE (n = 6 rats). In the same column, the presence of different letters (a–f) indicating a significant difference between groups using ANOVA in SPSS software (at p < 0.05), the letter “a” is the nearest result to the control while letter ”f” is the furthest from the control group.