Table 4.
Effect of different treatments on the markers of liver function (AST, ALT and ALP).
| Group | AST, Percent * | ALT, Percent * | ALP, Percent * |
|---|---|---|---|
| Normal control | 22.7 ± 1.28 a | 48.8 ± 1.35 a | 141.3 ± 6.75 a |
| Negative control | 50.8 ± 3.05 d, 122% (↑) | 116 ± 3.27 d, 137.5% (↑) | 232.9 ± 10.5 c, 64.8% (↑) |
| MTX treated group | 66.3 ± 2.52 f, 31.1% (↑) | 159.8 ± 6.58 g, 37.8% (↑) | 378.3 ± 8.85 f, 62.4% (↑) |
| Ethanolic extract (100 mg/Kg b.wt) | 40.3 ± 1.33 c, 19.9% (↓) | 101.5 ± 3.22 c,12.5% (↓) | 176.8 ± 5.92 b, 24.1% (↓) |
| Ethanolic extract (200 mg/Kg b.wt) | 29.8 ± 1.17 b, 40.7% (↓) | 74.2 ± 2.41 b, 36.1% (↓) | 156.6 ± 3.98 a,b, 32.8% (↓) |
| MTX + ethanolic extract (100 mg/Kg b.wt) | 62.3 ± 2.96 e,f, 23.8% (↑) | 145.7 ± 3.80 f, 25.6% (↑) | 328.6 ± 7.33 e, 41.1% (↑) |
| MTX + ethanolic extract (200 mg/Kg b.wt) | 56.7 ± 1.94 e, 12.6% (↑) | 131 ± 5.7 e, 12.6% (↑) | 274.1 ± 13.2 d, 17.1% (↑) |
AST, aspartate amino transferase (U/mL); ALT, alanine transaminase (U/mL); and ALP, alkaline phosphatase (U/L).* percentage increase or inhibition. Values are expressed as mean ± SE (n = 6 rats). In the same column, the presence of different letters (a–f) indicating a significant difference between groups using ANOVA in SPSS software (at p < 0.05), the letter “a” is the nearest result to the control while letter ”f” is the furthest from the control group.