Table 2.

Marine-derived compounds in Phase III status.

Compound Name	Marine Organism	Chemical Class	Molecular Target (Target Hallmarks)	Cancer Type	References
Marizomib	Bacterium	β-lactone-γ lactam	20S proteasome	Non-small-cell lung cancer, pancreatic cancer, melanoma, lymphoma, multiple myeloma	[8,37,38,39,40,41,42,43]
Plinabulin	Fungus	Diketopiperazine	Microtubules	Non-small-cell lung cancer, brain tumor	[8,44,45,46,47]