Table 4.
Marine-derived compounds in phase I status.
| Compound Name | Marine Organism |
Chemical Class | Molecular Target (Target Hallmarks) |
Cancer Type | References |
|---|---|---|---|---|---|
| MORAb-202 | Sponge | ADC (macrolide) |
Microtubules | Solid tumors | [8,88,89] |
| XMT-1536 | Mollusk/ cyanobacterium |
ADC (dolaflexin) |
NaPi2b and microtubules | Solid tumors | [8,90,91,92,93,94] |
| RF06804103 | Mollusk/ cyanobacterium |
ADC (auristatin variant) |
HER2 | Breast neoplasms, stomach neoplasms, esophagogastric junction neoplasm, carcinoma, non-small-cell lung cancer | [8,95,96,97,98] |
| ARX-788 | Mollusk/ cyanobacterium |
ADC (MMAE) |
HER2 and microtubules | Breast cancer, gastric cancer | [8,99,100,101] |
| ALT-P7 | Mollusk/ cyanobacterium |
ADC (MMAE) |
HER2 and microtubules | Breast cancer, gastric cancer | [8,102,103] |
| ZW49 | Mollusk/ cyanobacterium |
ADC (auristatin variant) |
HER2 | HER2-expressing cancers | [8,104] |