Table 3.
DMTs were calculated by logistic regression (p < 0.05) for each pairwise comparison. From these DMTs, tiles with methylation differences over 10% were selected and split in tiles with increased methylation for each group.
| DMTs (Total 272053) | FEMALES | MALES | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p < 0.05 | + Methylation Difference > 10% | % | p < 0.05 | + Methylation Difference > 10% | % | |||||||||
| % Over Total | % Over Total | |||||||||||||
| INVIVO vs. FLUIDS | 78,979 | 47,969 | * | 17.63 | Up in INVIVO | 22,148 | 46.17 | 65,570 | 30,849 | * | 11.34 | Up in INVIVO | 15,122 | 49.02 |
| Up in FLUIDS | 25,821 | 53.83 | Up in FLUIDS | 15,727 | 50.98 | |||||||||
| INVIVO vs. BSA | 56,015 | 30,571 | 11.24 | Up in INVIVO | 15,776 | 51.60 | 75,793 | 40,885 | 15.03 | Up in INVIVO | 20,864 | 51.03 | ||
| Up in BSA | 14,795 | 48.40 | Up in BSA | 20,021 | 48.97 | |||||||||
| INVIVO vs. SERUM | 35,762 | 22,185 | * | 8.15 | Up in INVIVO | 12,999 | 58.59 | 77,265 | 33,389 | * | 12.27 | Up in INVIVO | 16,981 | 50.86 |
| Up in SERUM | 9,186 | 41.41 | Up in SERUM | 16,408 | 49.14 | |||||||||
| FLUIDS vs. BSA | 71,191 | 26,075 | * | 9.58 | Up in FLUIDS | 21,218 | 81.37 | 52,545 | 15,510 | * | 5.70 | Up in FLUIDS | 12,350 | 79.63 |
| Up in BSA | 4,857 | 18.63 | Up in BSA | 3,160 | 20.37 | |||||||||
| FLUIDS vs. SERUM | 49,662 | 27,937 | * | 10.27 | Up in FLUIDS | 13,010 | 46.57 | 67,148 | 27,412 | * | 10.08 | Up in FLUIDS | 14,487 | 52.85 |
| Up in SERUM | 14,927 | 53.43 | Up in SERUM | 12,925 | 47.15 | |||||||||
| SERUM vs. BSA | 48,251 | 26,563 | * | 9.76 | Up in SERUM | 12,434 | 46.81 | 71,791 | 32,638 | * | 12.00 | Up in SERUM | 15,368 | 47.09 |
| Up in BSA | 14,129 | 53.19 | Up in BSA | 17,270 | 52.91 | |||||||||
Significant differences in the number of DMTs with methylation difference >10% between each two groups were calculated by Chi-square (* p < 0.001) with respect to the DMTs between INVIVO and BSA groups, which was considered as the control for the in vitro groups.