Table 2.
Role of macroH2A in different cancers.
| Types of Cancer | Backgrounds | MacroH2A | Potential Mechanisms | References |
|---|---|---|---|---|
| Anal cancer | MacroH2A2 | - | [110] | |
| Bladder cancer | MacroH2A1 | Repression of calcium channel genes | [117] | |
| MacroH2A1.1 | Repression of Lin28B | [123] | ||
| Breast cancer | Triple-negative | MacroH2A1.1 | EMT involvement | [134] |
| MacroH2A1.2 | Promoting HER-2 signaling | [141] | ||
| Osteoclastogenesis | MacroH2A1.2 | Repression of LOX gene | [69] | |
| Colon cancer | MacroH2A1.1 | Promoting differentiation | [109] | |
| MacroH2A1 | Repression of p16 | [135] | ||
| Hepatocellular carcinoma | Steatosis-associated | MacroH2A1 | Metabolic implications | [66] |
| MacroH2A1 | Limiting drug response | [67] | ||
| MacroH2A1 | Reducing cancer stemness | [65] | ||
| MacroH2A1 | Loss of heterochromatin compaction | [81] | ||
| Lung cancer | MacroH2A1.1 | Senescence association | [108] | |
| MacroH2A1.1 | Metabolic implications | [61] | ||
| Melanoma | Cutaneous | MacroH2A1/2 | Regulation of CDK8 genes | [107,119] |
| Uveal | MacroH2A1 | Potential metabolic implications | [137] | |
| Myelodysplasia | UA2F1 mutation | MacroH2A1 | - | [114] |
| MacroH2A1.1 | Gene regulation of ribosomal biology | [113] | ||
| Prostate cancer | Osteoclastogenesis | MacroH2A1 | Regulation in LTβ | [124] |
| Teratoma | MacroH2A1 | Promoting differentiation | [116] |
Blue indicates macroH2A protein as a tumor suppressor, red indicates macroH2A protein as an oncogene.