Table 3.
In vitro activity data of boswellic acid derivatives against amastigote forms of Leishmania donovani; values represent geometric means of two independent determinations, the lower and upper values are reported in parentheses.
| No. |
Leishmania donovani Axenic Amastigotes |
Cytotoxicity against L6 Rat Skeletal Myoblasts |
|||
|---|---|---|---|---|---|
| IC50 (µg/mL) | IC50 (µM) | IC50 (µg/mL) | IC50 (µM) | SI | |
| 1 | 0.9 (0.51; 1.7) | 1.9 | 43 (42; 45) | 91 | 46 |
| 2 | 0.45 (0.37; 0.54) | 0.88 | 17 (17; 18) | 33 | 38 |
| 3 | 2.4 (1.5; 3.7) | 5.3 | 15 (14; 16) | 33 | 6.2 |
| 4 | 6.1 (3.1; 12) | 12 | 16 (16; 17) | 32 | 2.7 |
| 5 | n.a. (2.3; >100) | n.a. | 14 (14; 15) | 31 | n.a. |
| 6 | 3.1 (1.4; 6.9) | 6.2 | 7.2 (6.4; 8.0) | 14 | 2.3 |
| PCMa | 0.047 (0.035; 0.064) | 0.12 | n.a. | n.a. | n.a. |
| PCPb | n.a. | n.a. | 0.009 (0.007; 0.011) | 0.02 | n.a. |
| Intracellular Amastigotes c |
Cytotoxicity against
Macrophages |
||||
| 2 | > 10 | n.a. | 20 (20; 20) | 39 | n.a. |
| PCMa | 1.9 (2.6; 1.4) | 4.7 | n.a. | n.a. | n.a. |
SI: selectivity index; a positive control: miltefosine; b positive control: podophyllotoxin; c in peritoneal murine macrophages; n.a. = not available.