Table 4.
Effect of R. albiflorum essential oils and component compounds on Ca2+ influx in human neutrophils and microglial cells.
| Essential Oil or Pure Compound | Ca2+ Influx | |||
|---|---|---|---|---|
| Neutrophils | C20 cells | |||
| EC50 (µg/mL) | ||||
| REOLv | 18.6 ± 5.8 | 22.8 ± 1.6 | ||
| REOFl | N.A. | N.A. | ||
| REOLv | REOFl | EC50 (µM) | ||
| Composition (%) | ||||
| β-Phellandrene | 0 | 8.9 | N.A. | N.A. |
| Viridiflorol | 22.0 | 1.2 | 6.8 ± 2.3 | 27.8 ± 4.6 |
| Spathulenol | 14.4 | 0.3 | 39.4 ± 9.5 | N.A. |
| Curzerene | 17.8 | 2.2 | 37.6 ± 8.4 | 25.9 ± 5.2 |
| Germacrone | 3.3 | 0 | 24.0 ± 4.6 | 27.7 ± 2.5 |
EC50 values were determined by nonlinear regression analysis of the dose-response curves as described under Materials and Methods. N.A. indicates the samples had essentially no activity (EC50 >50 µM or >50 µg/mL). The data are presented as the mean ± SD of three independent experiments.