Table 6.

Potential protein targets identified by PharmMapper for germacrene B, germacrone, curzerene, (−)-viridiflorol, and (+)- and (−)-spathulenol.

Rank	PDB ID	Target Name	Fit Score	Rank	PDB ID	Target Name	Fit Score
Germacrene B				Germacrone
1	1J96	AKR1C2	0.9912	1	1J96	AKR1C2	0.9926
2	1REU	BMP2	0.9846	2	1PMV	JNK3	0.9911
3	2P3G	MAPKAPK2	0.9817	3	1UKI	JNK1	0.9909
4	2PG2	KIF11	0.9735	4	2PIN	NR1A2	0.9712
5	1P49	Steroid sulfatase	0.9567	5	1P49	Steroid sulfatase	0.9586
6	1SHJ	Caspase-7	0.9481	6	2PG2	KIF11	0.9537
7	1E7E	Serum albumin	0.9419	7	1L6L	Apo A-II	0.9489
8	2O65	PIM1	0.9295	8	1RS0	CFB	0.9415
(−)-Curzerene				( + )-Viridiflorol
1	1REU	BMP2	0.9904	1	1XDD	Integrin α-L	3
2	2PIN	NR1A2	0.9873	2	1J96	AKR1C2	3
3	2O65	PIM1	0.9861	3	3BMP	BMP2	3
4	2P3G	MAPKAPK2	0.9764	4	2P3G	MAPKAPK2	2.906
5	1UKI	JNK1	0.975	5	1IF4	CA2	2.886
6	1PMV	JNK3	0.9671	6	3CJF	VEGFR2	2.881
7	1RS0	CFB	0.9652	7	1SHJ	Caspase-7	2.708
8	1SHJ	Caspase-7	0.9594	8	3CGF	JNK3	2.568
(−)-Spathulenol				(+)-Spathulenol
1	1XDD	Integrin α-L	2.968	1	2P3G	MAPKAPK2	2.952
2	1NO9	Prothrombin	2.948	2	3BMP	BMP2	2.947
3	3BMP	BMP2	2.947	3	1XDD	Integrin α-L	2.895
4	1J96	AKR1C2	2.921	4	1NO9	Prothrombin	2.802
5	1E7A	Serum albumin	2.804	5	1SHJ	Caspase-7	2.793
6	1PMV	JNK3	2.789	6	1PMV	JNK3	2.736
7	2P3G	MAPKAPK2	2.749	7	2O65	PIM1	2.723
8	1P49	Steroid sulfatase	2.739	8	1J96	AKR1C2	2.722

AKR1C2, aldo-keto reductase family 1 member C2 (bile acid binding protein); Apo A-II, apolipoprotein A-II; CA2, carbonic anhydrase 2; CFB, complement factor B; BMP2, bone morphogenetic protein 2; DBP, vitamin D-binding protein; KIF11, kinesin-like protein; MAPKAPK2, MAP kinase-activated protein kinase 2; PIM1, serine/threonine-specific proviral integration site for Moloney murine leukemia virus; NR1A2, thyroid hormone receptor β; p-38, mitogen-activated protein kinase 14; JNK1, mitogen-activated protein kinase 8; JNK3, mitogen-activated protein kinase 10; and VEGFR2, vascular endothelial growth factor receptor 2.