FIG 1.

Waterfall plot of the maximal tumor burden changes relative to the baseline burden. One patient (#) experienced an initial tumor increase meeting the criteria for PD followed by tumor shrinkage of ≥ 30% decrease compared with the baseline (pseudoprogression). One patient achieved a 100% decrease of the target lesions (*); however, the nontarget lesions did not disappear completely and thus had partial response as the best overall response. One patient had +103.6% increase of tumor burden at best overall response (◊) that is beyond the maximum value of the y axis in the graph. BOR, best overall response.