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Overall spectrum and penetrance of pathogenic variants detected. Penetrance key: Red: high-risk cancer gene associated with colon cancer with or without other cancers. Orange: moderate- or low-risk cancer gene associated with colon cancer with or without other cancers. Green: high- or moderate-risk cancer gene not typically associated with colon cancer. Purple: low-risk cancer gene not typically associated with colon cancer. Blue: no increased cancer risk for monoallelic carriers.
