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. Author manuscript; available in PMC: 2021 Jun 29.
Published in final edited form as: Immunometabolism. 2021 Jun 2;3(3):e210024. doi: 10.20900/immunometab20210024

Figure 2. Effect of DAMPs and cholesterol-enriched medium on gene expression in murine bone marrow derived macrophages through IRF7.

Figure 2.

IRF7 is linked to regulation of cholesterol- and inflammation-modulating genes in macrophages. In murine bone marrow derived macrophages, incubation with DAMP-enriched cholesterol-enriched medium resulted in increased expression of Abca1, Abcg1, Nr1h2 (LXRβ) and Nr1h3 (LXRα), and decreased expression of Cd36; regulation of these factors was reversed by knockdown of Irf7. Furthermore, with respect to inflammation, siRNA-knockdown of Irf7 upregulated Arg1 and Il10, and significantly downregulated Tnfa, Nos2, Il6, and Ccl2 in bone marrow derived macrophages [92]. In those studies, it was shown that RAGE ligands upregulate Irf7 in macrophages.