Fig. 6. Role of DNMTs in the rejuvenation event.

(A) We applied rDNA clocks to single KO of DNMT1 (Dnmt1^−/−), double KO of DNMT3A and DNMT3B (DKO), wild type (WT), and heterozygous control (3a^−/+ and 3a^−/+ 3b^−/+) embryos at E8.5 (dataset 19). (B) Application of four genome-wide epigenetic aging clocks to the same dataset. Two-sided t tests were calculated (ns, P > 0.05; *, 1 × 10⁻² < P ≤ 5 × 10⁻²; **, 1 × 10⁻³ < P ≤ 1 × 10⁻²; ***, 1 × 10⁻⁴ < P ≤ 1 × 10⁻³; ****P ≤ 1 × 10⁻⁴).