Table 2. Epigenetic aging clocks used in this study.
AD, Alzheimer’s disease; CR, calorie restriction; F, female; GHRKO, growth hormone receptor knockout; M, male; PD, Parkinson’s disease; WD, Werner syndrome.
| Clock | Reference | Species | Tissue | Method | Age range | Gender | Model |
No. clock sites |
Acc. on test |
Age-related condition sensitive for |
| Human multi-t. | (18) | Human | Multi | 27K array | Full lifespan | F & M | EN | 353 | r = 0.96 | E.g., mortality, cogn. perform., frailty, AD, PD, WD, centenarian status, iPSC |
| Petkovich blood | (30) | Mouse C57BL/6 |
Blood | RRBS | Full lifespan | M | EN | 90 | R2 = 0.9 | CR, GHRKO, SD, iPSC |
| Stubbs multi-t. | (31) | Mouse C57BL/6 |
Multi | RRBS | 1–41 weeks | M | EN | 329 | r = 0.84 | Low-fat diet |
| Meer multi-t. | (33) | Mouse C56BL/6 |
Multi | RRBS | Full lifespan | F & M | EN | 435 | R2 = 0.89 | GHRKO, iPSC |
| Thompson multi-t. EN |
(34) | Mouse mostly C57BL/6J, BALB/cBy |
Multi | RRBS | Full lifespan | F & M | EN | 582 | r = 0.89 | CR, Ames dwarf |
| Blood rDNA | (35) | Mouse C57BL/6 |
Blood | RRBS, only rDNA |
Full lifespan | M | EN | 72 | r = 0.92 | CR, GHRKO, iPSC |
| Multi-t. rDNA | This study | Mouse C57BL/6 |
Multi | RRBS, only rDNA |
1.7–21.3 months | F & M | EN | 355 | r = 0.94 | CR, GHRKO, iPSC |