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. 2021 Jun 11;15:680042. doi: 10.3389/fnbeh.2021.680042

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Copyright © 2021 Wooden, Spinetta, Nguyen, O’Leary and Leasure.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mice of both sexes showed a significant preference for NO1 over the two familiar objects. Both females (A,B) and males (C,D) spent a greater percentage time than chance (dotted red line) exploring NO2. Panels (B,D) show the data averaged across all three trials. Numbers below the X-axis in panels (A,C) indicate the number of animals that contacted NO1 during each trial. Effect sizes (Cohen’s d) are indicated below the X-axis in panels (B,D), and were calculated as a marker of practical significance for exploration differences between NO1 and NO2.