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. 2021 Jun 21;14:3803–3812. doi: 10.2147/OTT.S315998

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© 2021 Zhang et al.

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Cholesterol homeostasis in the activated CD8+ T cell: Newly activated CD8 T cells increase cholesterol biosynthetic and input and decrease outflow via the action of SREBP and LXR transcription factors. In addition, cholesterol esterification genes, specifically ACAT1, were significantly downregulated in activated CD8 T cells.

Abbreviations: TCR, T cell receptors; HDL, high-density lipoprotein; LDL, low-density lipoprotein; ACAT-1, acetyl-coA acetyltransferase 1; HMGCR, 3-hydroxy-3- methylglutaryl-Coenzyme A reductase; LXR, liver X receptor; SREBP, sterol regulatory element binding protein.