Table 3.
Median (IQR) Secondary Outcomes Scores for Each Group, and Results of GEE Analysis (PP Analysis, n = 200; Experimental Group n = 105, Control Group n = 95)
| Outcome Measure | Baseline (t0) | 7 Days (t1) | 4 Weeks (t2) | 12 Weeks (t3) | Treatment ˄ | Time Effect ˄ | Treatment× Time Effect ˄ | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Experimental Group | Control Group | Experimental Group | Control Group | Experimental Group | Control Group | Experimental Group | Control Group | Wald Chi-Square | P value | Wald Chi-Square | P value | Wald Chi-Square | P value | |
| MBI | 31.00 (20.00–50.00) | 28.00 (20.00 −56.00) | 52.00 (25.50 −77.50) | 39.00 (23.00 −68.00) | 75.00 (51.50–97.00) | 68.00 (42.00 −87.00) | 90.00 (71.50 −100.00) | 81.00 (60.00 −98.00) | 1.362 | 0.243 | 945.421 | <0.001* | 16.319 | 0.001* |
| NIHSS | 6.00 (4.00 −9.00) | 6.00 (3.00 −10.00) | 5.00 (2.00–6.50) | 4.00 (2.00–9.00) | 2.00 (0.00–4.00) | 2.00 (1.00 −4.00) | 0.00 (0.00 −1.00) | 1.00 (0.00 −2.00) | 0.421 | 0.516 | 507.837 | <0.001* | 6.732 | 0.081 |
| mRS | 4.00 (4.00 −4.00) | 4.00 (4.00 −4.00) | 4.00 (3.00–4.00) | 4.00 (3.00–4.00) | 3.00 (3.00–4.00) | 3.00 (3.00 −4.00) | 2.00 (1.00–3.00) | 3.00 (2.00 −3.00) | 0.716 | 0.397 | 272.803 | <0.001* | 5.176 | 0.159 |
Notes: ˄Results of Generalized estimating equation (GEE) analysis for group by time effect across all timepoints; *P < 0.05/3 = 0.0167.
Abbreviations: IQR, interquartile range; MBI, modified Barthel index; NIHSS, National Institutes of Health Stroke Scale; mRS, modified Rankin Scale.