Table 3.

Univariate and Multivariate Cox Regression Analysis of Disease-Free Survival in PAAD Patients

Variables	Univariate		Multivariate
	P value	HR (95% CI)	P value	HR (95% CI)
Age
<60	Reference
≥60	0.851	1.045(0.663–1.647)
Gender
Female	Reference
Male	0.578	0.883(0.57–1.369)
Histological type
Ductal type	Reference
Other subtype	0.007	0.407(0.213–0.78)	0.377	0.713(0.336–1.513)
Colloid carcinoma	0.997	–	0.998	–
Undifferentiated	0.998	–	0.999	–
Unknown	0.998	–	0.999	–
Grade
G1	Reference
G2	0.03	2.131(1.076–4.222)	0.202	1.595(0.779–3.265)
G3+G4	0.002	3.024(1.481–6.177)	0.101	1.858(0.886–3.894)
Gx	0.099	5.72(0.721–45.406)	0.135	5.276(0.594–46.6)
T classification
T1+T2	Reference
T3+T4	0.021	2.138(1.121–4.078)	0.962	1.026(0.359–2.926)
TX	0.997	–	1	–
Unknown	0.997	–	0.998	–
N classification
N0	Reference
N1	0.026	1.753(1.068–2.878)	0.284	1.421(0.747–2.704)
NX	0.995	–	0.998	–
Unknown	0.997	–	0.998	–
M classification
M0	Reference
M1	0.861	0.881(0.213–3.638)	0.998	0.997(0.08–12.48)
MX	0.005	0.521(0.329–0.825)	0.061	0.632(0.391–1.022)
Stage
I	Reference
II	0.014	2.688(1.217–5.937)	0.845	1.15(0.286–4.627)
III+IV	0.172	2.599(0.659–10.24)	0.872	1.217(0.111–13.31)
Unknown	0.995	–	–	–
Family history
No	Reference
Yes	0.818	1.065(0.62–1.831)
Unknown	0.84	1.059(0.605–1.855)
Chronic pancreatitis
No	Reference
Yes	0.623	0.776(0.282–2.137)
Unknown	0.371	0.737(0.378–1.438)
Diabetes history
No	Reference
Yes	0.817	0.933(0.52–1.674)
Unknown	0.126	0.561(0.268–1.176)
Alcohol history
No	Reference
Yes	0.307	1.284(0.795–2.073)
Unknown	0.525	0.732(0.279–1.919)
Adjuvant chemotherapy
No	Reference
Yes	0.997	1.001(0.583–1.719)
Unknown	0.797	1.1(0.532–2.276)
Adjuvant radiotherapy
No	Reference
Yes	0.551	0.849(0.495–1.455)
Unknown	0.807	0.927(0.502–1.711)
KRT7
Low	Reference
High	0.000	2.313(1.476–3.626)	0.019	1.793(1.097–2.933)