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Design of the study. Effects of recombinant human ZPI (rhZPI) was analysed either in whole blood or on isolated fractions of blood (monocytes alone, monocytes and lymphocytes, in the presence or not of platelets or polymorphonuclear cells, and with normal plasma or coagulation factor deficient plasmas). Lipopolysaccharide (LPS) from E. coli 0111:B4 was used to stimulate monocytes or to induce in vivo inflammation
