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. 2021 Jun 25;5(2):e220–e229. doi: 10.1055/s-0041-1730037

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — Effects of the rhZPI-Y387A variant on the secretion of IL-6 and TNF-α in whole blood activated by lipopolysaccharide (LPS). Comparison with wild-type rhZPI (ZPI) effects. Cytokines were quantified after a 20 hours incubation. rhZPI-Y387A or rhZPI were added at 250 nM 30 min before the addition of LPS (10 ng/mL). Results are expressed as percentages of IL-6 or TNF-α production in the absence of ZPI (controls) which were considered arbitrarily as 100%. Results (mean ± 1 SEM) are the average of 6 independent experiments in triplicate. ^### p < 0.001 as compared to the production of cytokines in the presence of LPS alone, ^*** < 0.001 as compared to the production of cytokines in the presence of wild-type ZPI (Dunnett’s multiple comparisons test following one-way ANOVA).