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Spleen of ChAdOx1 nCoV-19-immunized mice of the indicated ages
Confocal microscopy of spleen from ChAdOx1 nCoV-19 immunized mice where germinal center structures can be easily observed in adult mice (A), but mostly absent in the aged group (B). The scale bars represent 500 μm. IgD+ B cell follicle in green, CD3+ T cells in magenta, Ki67+ cells in blue and CD35+ follicular dendritic cells in white. Germinal centers are indicated with white arrowheads.
