Table 3.
Calculated IC50 values of pyruvate-modulated extracellular acidification rate across the cell panel
| Cells | IC50 (mM) ECAR |
|---|---|
| Panc03.27 | 0.42 ± 0.09 |
| Mia Paca2 | 2.03 ± 0.30 |
| QGP1 | 0.54 ± 0.08 |
| MDA-MB-231 | 9.42 ± error nonconvergent |
| HPNE | NA |
IC50 values for pyruvate-modulated glucose-induced extracellular acidification rate (ECAR) for various cell lines as determined by nonlinear regression of log[inhibitor] VS response model using four-parameter variable slope with the constraint that the bottom of the curve fit equals 0.5. Standard errors were included. NA, no inhibition observed. All experiments were done in quintuplicate (technical replicates); n = 3, independent experiments (biological replicate); mean values with standard errors.