Table 3.

List of putative loss-of-function VUS (frameshift deletion, stop gain, start loss, splice site variant)

Gene (Reference sequences)	Variant nomenclature	Variant classification	Cancers diagnosed in the patient
APC	c.1A > G, p.Met1Val	Start loss	Ovary
BRCA2	c.8954-5_8954-2delAACA	Splice variant	Ovary
	c.7617 + 2dupT	Splice variant	Primary Peritoneal
MSH2	c.792 + 3A > T	Splice variant	Breast
RECQL	c.2 T > C, p.Met1Thr	Start loss	Breast
RECQL	c.2 T > C, p.Met1Thr	Start loss	Breast
RAD51C	c.571 + 5G > A	Splice variant	Breast
XRCC2 (NM_005431.1)	c.832G > T, p.Glu278*	Stop gain	Breast