Fig. 2.

Ciliary disassembly mechanism. a A schematic representation of ciliary resorption versus ciliary excision. b The core axis of ciliary disassembly is regulated through the NEDD9/AURKA/HDAC6 pathway that drives ciliary resorption. This axis can be stimulated by the mitochondria, extracellular WNT signalling and cell cycle regulators. The criteria for a protein to be considered a ciliary resorption protein, and to be included in this schematic overview, the protein has to influence ciliary length during disassembly, but is not involved in ciliary excision or budding. All of these proteins with a confirmed role in ciliary resorption are shown in blue. In addition to these, proteins shown in grey and with dotted lines indicate known interactors of these resorption proteins, but which have not yet been investigated in the context of ciliary resorption specifically. PLK1 both stimulates and inhibits ciliary resorption by phosphorylation of a wide variety of targets. The APC/C stimulates ciliary resorption when activated by CDC20. For CENPJ, the exact role in ciliary resorption remains elusive