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. 2021 Jun 25;12:3958. doi: 10.1038/s41467-021-24232-3

Fig. 7. Molecular responses of human and mouse astrocytes to poly I:C and TNFα.

Fig. 7

a Experimental design. b–e The number of significantly up or downregulated genes in poly I:C- and TNFα-treated human and mouse astrocytes. Genes with FDR < 0.05, fold change > 1.5, and average RPKM of control or treated groups > 1 are shown. f, g Fold changes of Tlr3, NFκB, and interferon response pathway genes in poly I:C- and TNFα-treated human and mouse astrocytes. Asterisks represent significance determined by DESeq2. h Selected antigen presentation-related GO terms enriched in poly I:C-induced genes only in human astrocytes. i–n Expression of the top 3 highest-expressing MHC Class I antigen presentation genes in poly I:C-treated and control human and mouse astrocytes. N = 4 litters of mice and 4 human patients. Mouse: H2-K1, p = 0.0051; H2-T24, p = 0.0019. Human: HLA-A, p < 0.0001; HLA-C, p < 0.0001; HLA-E, p < 0.0001. Multiple comparison-adjusted p values were calculated by the DESeq2 package. N.S., not significant.