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. 2021 Jun 25;7:81. doi: 10.1038/s41523-021-00283-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Representative IHC images showing high (top panel) and low (lower panel) expression of perinuclear STING, CD3, CD4, CD8, CD45RO, PD-L1 (SP263), PD-L1 (SP142), IDO1 and ICOS. b Heatmap of normalized expression measured by IHC of perinuclear STING, stromal STING, tumor STING, CD3, CD4, CD8, CD45RO, PD-L1 measured by SP263 and SP142, IDO1 and ICOS in ER + breast cancer cases. c Heatmap of normalized immune scores derived from deconvolution of microarray data in ER+ breast cancer cases. Correlation between markers and pnSTING stratified based on high (above median) and low (below median) was assessed using the Krushall Wallis test on non-transformed data with *, **, and *** indicating a p values of <0.05, <0.01, and <0.001, respectively.