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. 2021 Jun 25;7:81. doi: 10.1038/s41523-021-00283-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Kaplan Meier Curve analysis of relapse free survival (RFS; months) in a ER positive (ER + ), b ER negative (ER-) and c all samples with gene expression data only from discovery dataset stratified by pnSTING signature score threshold of the IHC cohort. Kaplan Meier Curve analysis of overall survival (months) in d ER + disease (all treatments) e those receiving hormone therapy only f those receiving chemotherapy in the METABRIC dataset stratified by pnSTING signature score. Kaplan Meier Curve analysis of overall survival (months) in ER+ disease from g TCGA 2012 dataset and h Wang dataset stratified by pnSTING signature score. Clinicopathological and molecular characteristics of METABRIC samples classified by pnSTING gene expression score comparing. i Tumor grade (adj. p < 0.0001). j Hormone therapy (adj. p = 0.009). k Chemotherapy (adj. p = 0.048). Clinicopathological and molecular characteristics of TCGA samples classified by pnSTING gene expression score comparing. l PAM50 subtype (adj. p < 0.0001) and m Fraction genome altered (adj. p < 0.0001).