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. 2021 Jun 25;7:81. doi: 10.1038/s41523-021-00283-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a GSEA results showing Normalized Enrichment Scores (NES) for the gensets enriched >±1 in pnSTING^high signature (red) or pnSTING^low signature (blue) samples. b Enrichment plots for the top 3 genesets enriched in pnSTING^high signature or pnSTING^low signature samples. c Correlation matrices for (left) ER positive and (right) ER negative breast cancer for pnSTING value, gene expression of DNA and RNA sensors and 18-gene interferon signature. d Percentage of ER+ cases with mutations in TP53, PIK3CA and MAP3K1 in the METABRIC (left) and TCGA (right) 2012 datasets stratified based on high (above median) and low (below median) STING signature score. e Expression of p-mTOR (Ser2448) quantified using QuPath in the discovery dataset stratified based on ER expression and perinuclear STING expression (where red = pnSTING^high and blue = pnSTING^low). Percentage of ER+ cases with copy number alteration f overall (with significance indicated in blue) in the METABRIC dataset and g of MYC and CCND1 in the METABRIC and TCGA 2012 datasets stratified based on high (above median) and low (below median) STING signature score.