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. 2021 Jun 25;4:799. doi: 10.1038/s42003-021-02215-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a BCL-2 and MCL1 protein expression analysis in MV4-11/MOLM-13 MID-Res compared to MID-Sens cells, in MV4-11/MOLM-13 MID-Res ± 50 nM Mid compared to MID-Sens ± 50 nM Mid. b Venetoclax (Ve) IC50 analysis in MV4-11/MOLM-13 MID-Sens and MID-Res cells treated with Ve during 48 h. c BCL-2 and MCL1 protein expression analysis in MV4-11/MOLM-13 MID-Res treated with Mid and Eht alone/combination. d Cell viability and synergy analysis in MV4-11/MOLM-13 MID-Res treated with Mid, Ve, and Eht alone/combination during 48 h. e BCL-2 and MCL1 protein expression and cell death analysis (Annexin V + /PI- + Annexin V + PI+) in DMSO (control), Mid (p = 0.76, t = 0.34, df = 2.3), Ve (p = 0.054, t = 2.7, df = 3.6), Eht (p < 0.05, 3.1, df = 3.7) and Mid + Eht (p < 0.01, t = 10.29, df = 3) Mid + Ve (p < 0.01, t = 8, df = 3.8) Ve + Eht (p < 0.001, t = 14, df = 3.9) and Eht + Ven + Mid (p < 0.001, t = 16.1, df = 3.2) during 24 h. f Cell death analysis by flow cytometry in REF001/REF002 AML samples and in PBMCs obtained from Healthy Donors HD4/HD5/HD6 treated with Mid, Eht, and Ve alone/combination during 24 h. The western blot results are normalized by loading control (GAPDH) and are expressed as fold change relative to the control. Data are shown as means ± SDs (error bars) from three independent experiments.