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. 2021 Jun 25;11:13305. doi: 10.1038/s41598-021-92552-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ciprofloxacin inhibits NEPC tumor growth and suppresses expression of neuroendocrine markers in vivo. (A,B) Tumor growth curves, tumor images, and tumor weights of TD-NEPC (tumor n = 7–9) (A) and NCI-H660 (tumor n = 6–7) (B) treated daily with vehicle or ciprofloxacin (50 mg/kg via intraperitoneal injection). Error bars represent standard error of the mean (SEM). *p < 0.05, **p < 0.01, ***p < 0.001, and n.s. = not significant, determined by Student’s t test. (C) IHC staining for MCM3, AR, CHGA, SYP, and Ki67 in NCI-H660 tumor xenografts treated with vehicle (Veh) or ciprofloxacin (CPX). Scale bars = 25 microns (upper panels) and 10 microns (lower panels). (D) Percentage of Ki67-positive cells per image. Error bars represent standard deviation. ****p < 0.0001 by Student’s t test.