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. 2021 Jun 25;12:3968. doi: 10.1038/s41467-021-24243-0

Fig. 5. Comparison of SCZ and BD risk genes.

Fig. 5

a The SNP-based heritability enrichment of SCZ and BD GWAS in differential NeuN+ and NeuN− peaks demonstrates neuronal enrichment (SCZ NeuN+, FDR = 9.33e-24; SCZ NeuN−, FDR = 2.14e-16; BD NeuN+, FDR=3.94e-15; BD NeuN−, FDR=6.09e-07). Enrichment ± standard error is depicted. The red broken line indicates heritability enrichment = 1. Source data are provided as a Source Data file. b The SNP-based heritability enrichment of SCZ and BD GWAS in differential Glu and GABA peaks suggests that both Glu and GABA neurons are associated with the psychiatric disorders (SCZ GABA, FDR = 4.54e−9; SCZ Glu, FDR = 3.49e−10; BD GABA, FDR=1.10e−03; BD Glu, FDR = 3.63e−06). Enrichment ± standard error is depicted. The red broken line indicates heritability enrichment = 1. Source data are provided as a Source Data file. c Neuronal subtype expression profiles of SCZ and BD risk genes detected by GABA and Glu H-MAGMA.