Table 2.
The laboratory and ROTEM values at ICU presentation and 3 months follow-up.
| ICU (N = 13) | Follow-up (N13) | p value | |||
|---|---|---|---|---|---|
| Median | [IQR] | Median | [IQR] | ||
| Laboratory variables (normal values) | |||||
| Haemoglobin (12.5–17.2 g/dL) | 9.9 | [8.7–11.0] | 13.6 | [10.6–14.1] | 0.006 |
| White blood cells (3.5–10.5/nl) | 12.8 | [8.0–13.6] | 7.1 | [5.3–9.1] | 0.023 |
| Platelet count (150–370/nl) | 142.0 | [116.0–271.5] | 224.0 | [193.5–237.0] | 0.263 |
| Prothrombin time (70–130%) | 79.0 | [64.0–86.5] | 85.0 | [78.5–96.5] | 0.196 |
| INR (0.9–1.25) | 1.2 | [1.1–1.4] | 1.1 | [1.0–1.2] | 0.173 |
| aPTT (26–40 s) | 56.4 | [49.2–62.0] | 36.8 | [34.4–43.7] | 0.033 |
| d-dimers (< 0.5 mg/l) | 4.8 | [3.9–7.8] | 0.4 | [0.3–0.8] | 0.001 |
| Fibrinogen (1.6–4 g/l) | 6.7 | [4.7–8.3] | 3.6 | [2.9–4.5] | 0.006 |
| IL-6 (< 7 ng/l) | 173.0 | [68.0–358.0] | 2.9 | [2.1–6.3] | 0.002 |
| CRP (< 0.5 mg/l) | 191.0 | [121.0–314.4] | 3.0 | [1.6–5.4] | 0.001 |
| Ferritin (30–400 µg/l) | 2408.7 | [1441.5–5280.5] | 190·4 | [108.6–288.2] | 0.002 |
| ROTEM variables (reference ranges) | |||||
| FIBTEM CT (43–69 s) | 92.0 | [86.5–104.5] | 99.0 | [68.0–110.5] | 0.463 |
| FIBTEM CFT (n/a s) | 101.0 | [54.5–200.5] | 198.0 | [57.5–559.0] | 0.225 |
| FIBTEM A10 (9–24 mm) | 29.0 | [24.0–35.5] | 15.0 | [13.0–21.5] | 0.002 |
| FIBTEM MCF (9–25 mm) | 32.0 | [27.0–39.0] | 16.0 | [14.0–24.0] | 0.002 |
| EXTEM CT (42–74 s) | 88.0 | [83.5–101.0] | 79.0 | [62.5–100.5] | 0.039 |
| EXTEM CFT (46–148 s) | 54.0 | [42.0–64.5] | 64.0 | [48.5–82.5] | 0.208 |
| EXTEM A10 (43–65 mm) | 66.0 | [63.0–68.5] | 59.0 | [54.5–62.5] | 0.033 |
| EXTEM MCF (49–71 mm) | 73.0 | [71.5–76.0] | 66.0 | [63.5–70.0] | 0.004 |
| INTEM CT (137–246 s) | 215.0 | [187.5–258.0] | 189.0 | [176.5–201.5] | 0.019 |
| INTEM CFT (40–100 s) | 56.0 | [50.5–60.5] | 71.0 | [52.5–79.5] | 0.075 |
| INTEM A10 (44–68 mm) | 64.0 | [60.0–70.5] | 57.0 | [53.5–59.5] | 0.006 |
| INTEM MCF (52–72 mm) | 73.0 | [70.0–76.5] | 63.0 | [59.5–67.5] | 0.003 |
| ML EXTEM (0–18%) | 3.0 | [3.0–5.0] | 8.0 | [6.0–12.0] | 0.002 |
| ML INTEM (0–12%) | 2.0 | [2.0–4.0] | 8.0 | [6.0–13.0] | 0.002 |
Unless values are designated as maximum values during the ICU stay, these parameters were determined on the day, when ROTEM analysis was performed, after admission to our ICUs.
CT Clotting time, CFT clot formation time, MCF maximum clot firmness, ML maximum lysis55.