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. 2021 Jun 25;12(7):649. doi: 10.1038/s41419-021-03920-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A TNF-α increases HMVECs migration. HMVECs were treated or not for 96 h with 100 ng/ml of TNF-α and were allowed to migrate in a modified Boyden chamber assay for an additional 3 h30. B TNF-α decreases the number of Ac-LDL-labelled endothelial cells. C TNF-α induces a reduction in tubules formation in a matrigel-based tube-formation assay. Tube formation and Ac-LDL scores were measured for three fields. Scale bars, 1000 µm. Migration was measured for six fields. Similar results were obtained in three different experiments. Significant differences are indicated by solid lines (**P < 0.05, ***P < 0.005 by t test). HMVEC human microvascular endothelial cell, Ctrl control, TNF-α tumour necrosis factor-α.