Table 5.
Association between serum levels of biomarkers, progression and mortality.
| Progression | p | Death | p | |||
|---|---|---|---|---|---|---|
| Yes | No | Yes | No | |||
| IL-1 | 6.1 (4.3) | 7.4 (16.0) | 0.372 | 6.2 (4.4) | 7.1 (14.0) | 0.608 |
| IL-2R | 428.4 (258.5) | 445.9 (248.4) | 0.534 | 501.2 (312.4) | 424.5 (234.1) | 0.067 |
| IL-6 | 8.7 (9.6) | 7.9 (8.6) | 0.429 | 11.1 (8.7) | 7.5 (8.9) | 0.004* |
| IL-8 | 44.7 (38.9) | 30.7 (36.5) | 0.001* | 58.2 (50.4) | 30.1 (29.1) | 0.001* |
| TNF-α | 7.9 (21.2) | 7.0 (14.9) | 0.669 | 7.6 (21.l) | 7.3 (16.8) | 0.896 |
| TGF-β | 20.5 (7.7) | 19.9 (7.3) | 0.493 | 19.7(7.2) | 20.2 (7.5) | 0.650 |
| LDH | 400.6 (107.1) | 364.3 (91.5) | 0.001* | 445.5 (124.7) | 363.4 (84.7) | < 0.001** |
| Alpha1AT | 148.9 (35.6) | 138.5 (36.1) | 0.011* | 173.2 (38.1) | 135.7 (31.5) | < 0.001** |
| Ferritin | 549.3 (519.3) | 471.4 (469.0) | 0.217 | 871.4 (866.4) | 432.2 (335.4) | 0.003* |
| CRP | 12.1 (16.7) | 9.5 (18.4) | 0.202 | 20.9 (23.0) | 8.0 (15.3) | < 0.001** |
IL1β Interleukin 1 beta, IL2R interleukin 2 receptor subunit alpha, IL-6 Interleukin 6, IL-8 interleukin 8, TNF-α Tumour necrosis factor alpha, TGF-β1 Transforming growth factor-beta 1, AAT alpha-1 antitrypsin, LDH lactate dehydrogenase, CRP C-reactive protein.
Statistical significance was determined using χ2 test and T Student test for qualitative and continuous variables, respectively.
*p < 0.05; **p < 0.001.