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. 2021 Jun 25;12(7):651. doi: 10.1038/s41419-021-03926-y

Fig. 4. Mutation of Parp rescues mitochondrial toxicity associated with the expression of Aβ-Arc.

Fig. 4

A Flies overexpressing Aβ-Arc have higher levels of poly ADP-ribosylation (mean ± SD; asterisks, two-tailed unpaired t test). B A Parp mutation increases NAD+ levels in Aβ-Arc-expressing flies (mean ± SD; asterisks, one-way ANOVA with Dunnett’s multiple comparison test). C A Parp mutation rescues the loss of Δψm in the brains of Aβ-Arc-expressing flies (means ± SD; asterisks, two-way ANOVA with Dunnett’s multiple comparison test). D A Parp mutation rescues the total percentage of time spent asleep, as well as sleep during the light phase (asterisks, one-way ANOVA with Tukey’s multiple comparison test for All phases and Light phase). E A Parp mutation rescues the neurodegeneration of photoreceptor cells in Aβ-Arc-expressing flies (asterisks, two-tailed chi-square test, 95% confidence interval). F A Parp mutation improves the lifespan of Aβ-Arc-expressing flies and significances were determined using the log-rank, Mantel–Cox test. Genotypes: control, daGal4>+ (A), elavGal4>+ (B–F); da>Aβ-Arc, daGal4>Aβ-Arc (A), elav>Aβ -Arc, elavGal4>Aβ-Arc (B–F).